Effects of Pulmonary Rehabilitation on Endurance and Quality of Life in Patients with Pulmonary Hypertension; A Randomized Controlled Trial

Pulmonary Rehabilitation in Pulmonary Hypertension

Authors

  • Ihsan Kareem Physiotherapy Department, Ammar Medical complex, Muridke, Pakistan
  • Kinza Amin University Institute of Physical Therapy, University of Lahore, Lahore, Pakistan
  • Anum Kabir PhysioHealth Clinic, Lahore, Pakistan
  • Aafrin Ataullah Central Park College of Physiotherapy, Lahore, Pakistan
  • Ahmad Ammar Asif 5Tehsil Head Quarters Hospital, Muridke, Pakistan
  • Mahina Aleem Riphah International University, Lahore, Pakistan

DOI:

https://doi.org/10.55735/hjprs.v3i12.244

Keywords:

endurance, pulmonary hypertension, pulmonary rehabilitation, quality of life

Abstract

Background: Pulmonary hypertension has been known as a rather serious condition as it affects the right side of the heart and eventually results in severe pulmonary conditions. The pulmonary arteries tend to become thick and inelastic. The functioning of the pulmonary system impairs and affects the oxygenation of the entire body. Objective: To determine the effects of pulmonary rehabilitation on endurance and quality of life in patients with pulmonary rehabilitation. Methods: Our current study is a randomized controlled trial. A purposive sampling technique was employed for sampling and 49 patients were randomly allocated into each group by lottery method. This trial was conducted at Bajwa Hospital, Shahdhrah, Lahore, Pakistan. The already diagnosed patients with pulmonary hypertension, employing World Health Organization with functional class II-IV were recruited in this study. The patients with heart failure NYHA class III and IV, mitral stenosis and systemic sclerosis were excluded from the study. The 6-minute walk test for endurance, Duke Activity Status Index for activity status and short form 36 for assessing quality of life were employed in the study. Results: The results of our study show that there is a significant difference between the groups pre and post-intervention. The majority of the data showed a p-value less than 0.05 so this indicates that data is not normally distributed and a non-parametric Mann-Whitney U test was applied between Groups 1 and 2 analysis for a 6-minute walk test. Both groups' baseline median for the 6-minute walk test had a p-value of 0.357 whereas for the 6-week median, the p-value was 0.000 which represents a statistical difference between the groups after the application of 6 weeks training program and medical treatment. Mann-Whitney U test was applied between Groups 1 and 2 analysis for Duke Activity Status Index score pre and post-intervention. Conclusion: This concluded that pulmonary rehabilitation significantly improves endurance, emotional well-being, general health, activity status and quality of life among patients with pulmonary hypertension.

References

Yan L, Shi W, Liu Z, et al. The benefit of exercise-based rehabilitation programs in patients with pulmonary hypertension: a systematic review and meta-analysis of randomized controlled trials. Pulmonary Circulation 2021; 11(2): 20458940211007810.

https://doi.org/10.1177/20458940211007810

Hoeper MM, Bogaard HJ, Condliffe R, et al. Definitions and diagnosis of pulmonary hypertension. Journal of the American College of Cardiology 2013; 62(25S): D42-D50.

https://www.jacc.org/doi/abs/10.1016/j.jacc.2013.10.032

Naranjo M, Hassoun PM. Systemic sclerosis-associated pulmonary hypertension: spectrum and impact. Diagnostics 2021; 11(5): 911.

https://www.mdpi.com/2075-4418/11/5/911

Yaqoob M, DeCato TW, Oudiz R. Pulmonary Arterial Hypertension (PAH) Group 1 (Part A): Overview, Classification, Clinical Subsets, and Workup. Current Respiratory Medicine Reviews 2024; 20(2): 88-106.

DOI: https://doi.org/10.2174/011573398X268623231212180622

Papasavvas T. Association between depression and cardiorespiratory fitness in general population and patients with heart disease: University of Essex; 2020.

https://repository.essex.ac.uk/26596/

Ryerson CJ, Nayar S, Swiston JR, Sin DD. Pharmacotherapy in pulmonary arterial hypertension: a systematic review and meta-analysis. Respiratory research 2010; 11: 1-10.

DOI

https://doi.org/10.1186/1465-9921-11-12

Gomberg-Maitland M, Bull TM, Saggar R, et al. New trial designs and potential therapies for pulmonary artery hypertension. Turk Kardiyoloji Dernegi Arsivi: Turk Kardiyoloji Derneginin Yayin Organidir 2014; 42: 106-18.

https://www.jacc.org/doi/abs/10.1016/j.jacc.2013.10.026

Galiè N, Hoeper MM, Humbert M, et al. Guidelines for the diagnosis and treatment of pulmonary hypertension: the Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS), endorsed by the International Society of Heart and Lung Transplantation (ISHLT). European heart journal 2009; 30(20): 2493-537.

https://doi.org/10.1093/eurheartj/ehr046

Aslan GK, Akıncı B, Yeldan I, Okumus G. A randomized controlled trial on inspiratory muscle training in pulmonary hypertension: Effects on respiratory functions, functional exercise capacity, physical activity, and quality of life. Heart & Lung 2020; 49(4): 381-7.

https://doi.org/10.1016/j.hrtlng.2020.01.014

Ehlken N, Lichtblau M, Klose H, et al. Exercise training improves peak oxygen consumption and haemodynamics in patients with severe pulmonary arterial hypertension and inoperable chronic thrombo-embolic pulmonary hypertension: a prospective, randomized, controlled trial. European heart journal 2016; 37(1): 35-44.

https://doi.org/10.1093/eurheartj/ehv337

Galiè N, Humbert M, Vachiery J-L, et al. 2015 ESC/ERS guidelines for the diagnosis and treatment of pulmonary hypertension: the joint task force for the diagnosis and treatment of pulmonary hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS): endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Heart and Lung Transplantation (ISHLT). European heart journal 2016; 37(1): 67-119.

https://doi.org/10.1093/eurheartj/ehv317

de Oliveira Gois M, Simões RP, Porta A, Kunz VC, Pastre CM, Catai AM. Cardiovascular responses to low-intensity isometric handgrip exercise in coronary artery disease: effects of posture. Brazilian journal of physical therapy 2020; 24(5): 449-57.

https://doi.org/10.1016/j.bjpt.2019.07.010

Zhang X, Xu D. Effects of exercise rehabilitation training on patients with pulmonary hypertension. Pulmonary Circulation 2020; 10(3): 2045894020937129.

https://doi.org/10.1177/2045894020937129

Campbell S, Greenwood M, Prior S, et al. Purposive sampling: complex or simple? Research case examples. Journal of research in Nursing 2020; 25(8): 652-61.

https://journals.sagepub.com/doi/abs/10.1177/1744987120927206

Haque M. Sampling methods in social research. Global Research Methodology 2010; 8(5): 1-6.

https://grmgrlaranya.org/Journals/SAMPLING%20METHODS%20IN%20SOCIAL%20RESEARCH.pdf

Villarta Jr RL, Asaad AS. Sample size determination in an epidemiologic study using the EpiTools web-based calculator. Acta Medica Philippina 2014; 48(1).

https://actamedicaphilippina.upm.edu.ph/index.php/acta/article/download/1192/1066

Agarwala P, Salzman SH. Six-minute walk test: clinical role, technique, coding, and reimbursement. Chest 2020; 157(3): 603-11.

https://doi.org/10.1016/j.chest.2019.10.014

Van de Hei S, Flokstra-de Blok B, Baretta H, et al. Quality of spirometry and related diagnosis in primary care with a focus on clinical use. NPJ Primary Care Respiratory Medicine 2020; 30(1): 22.

DOI https://doi.org/10.1038/s41533-020-0177-z

Riedel B, Li MH, Lee CA, et al. A simplified (modified) Duke Activity Status Index (M-DASI) to characterise functional capacity: a secondary analysis of the Measurement of Exercise Tolerance before Surgery (METS) study. British Journal of Anaesthesia 2021; 126(1): 181-90.

https://doi.org/10.1016/j.bja.2020.06.016

Ilardi F, D’Andrea A, D’Ascenzi F, et al. Myocardial work by echocardiography: principles and applications in clinical practice. Journal of Clinical Medicine 2021; 10(19): 4521.

https://www.mdpi.com/2077-0383/10/19/4521

Hernández JD, Spir MA, Payares K, et al. Assessment by proxy of the SF-36 and WHO-DAS 2.0. A systematic review. Journal of Rehabilitation Medicine 2023; 55.

doi: 10.2340/jrm.v55.4493

Zeng X, Chen H, Ruan H, Ye X, Li J, Hong C. Effectiveness and safety of exercise training and rehabilitation in pulmonary hypertension: a systematic review and meta-analysis. Journal of thoracic disease 2020; 12(5): 2691.

doi: 10.21037/jtd.2020.03.69

Keusch S, Turk A, Saxer S, Ehlken N, Grunig E, Ulrich S. Rehabilitation in patients with pulmonary arterial hypertension. Swiss medical weekly 2017; 147(2728): w14462-w.

DOI https://doi.org/10.4414/smw.2017.14462

Grünig E, Ehlken N, Ghofrani A, et al. Effect of exercise and respiratory training on clinical progression and survival in patients with severe chronic pulmonary hypertension. Respiration 2011; 81(5): 394-401. https://doi.org/10.1159/000322475

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Published

12/30/2023

How to Cite

Kareem, I., Amin, K., Kabir, A., Ataullah, A. ., Asif, A. A., & Aleem, M. (2023). Effects of Pulmonary Rehabilitation on Endurance and Quality of Life in Patients with Pulmonary Hypertension; A Randomized Controlled Trial: Pulmonary Rehabilitation in Pulmonary Hypertension. The Healer Journal of Physiotherapy and Rehabilitation Sciences, 3(12), 9–18. https://doi.org/10.55735/hjprs.v3i12.244

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