Predictors of Renal Dysfunction in Patients with Chronic Obstructive Pulmonary Disease
Predictors of Renal Dysfunction in Chronic Obstructive Pulmonary Disease
DOI:
https://doi.org/10.55735/hjprs.v5i1.313Keywords:
Chronic obstructive pulmonary disease, Predicators, Renal Dysfunction, Renal FailureAbstract
Background: Chronic obstructive pulmonary disease is typically a chronic disorder, the third most common reason for death worldwide but a significant figure of patients experience exacerbations, which are characterized as an acute worsening of respiratory symptoms imposing a change in treatment. Objective: To find the predictors of renal dysfunction in patients with chronic obstructive pulmonary disease. Methodology: It was a descriptive observational study and data was collected from the Services Hospital Lahore over a four-month duration. Non-probability purposive sampling technique was used to recruit 143 patients aged between 30 to 60 years of both genders. Patients diagnosed with chronic obstructive pulmonary disease according to GOLD definition. Excluded patients were patients with acute kidney injury or recent episodes of renal dysfunction from the past 3 months, patients already diagnosed with chronic kidney disease or having renal replacement therapy or mentally retarded patients. The data was analyzed through SPSS version 27. Quantitative variables were described using the mean and standard deviation, whereas frequencies and percentages were utilized for qualitative aspects. The Institutional Review Board reviewed the research proposal to ensure it adheres to ethical guidelines and protects participant rights. Results: There were 99 male patients, which is a total population of 69.2%, while there were 44 female patients, which is a total population of 30.8%. There is a significant result between chronic obstructive pulmonary disease severity and urine output. There is a significant result between urine output and hypoxia. The p-value is considered as significant <0.005. Conclusion: Chronic obstructive pulmonary disease can cause systemic inflammation, hypoxia and hypercapnia, as well as comorbid conditions that have a significant impact on kidney functions. Derangements in urea and creatinine levels have been linked to poorer outcomes in chronic obstructive pulmonary disease patients, including increased mortality and lower quality of life.
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References
Viniol C, Vogelmeier CF. Exacerbations of COPD. European Respiratory Review 2018; 27(147). DOI: https://doi.org/10.1183/16000617.0103-2017
Soriano JB, Polverino F, Cosio BG. What is early COPD and why is it important? European Respiratory Journal 2018; 52(6). DOI: https://doi.org/10.1183/13993003.01448-2018
Mirza S, Clay RD, Koslow MA, Scanlon PD. COPD guidelines: a review of the 2018 GOLD report. Mayo Clinic Proceedings; 2018: Elsevier; 2018. p. 1488-502. DOI: https://doi.org/10.1016/j.mayocp.2018.05.026
Mahmood T, Singh RK, Kant S, Shukla AD, Chandra A, Srivastava RK. Prevalence and etiological profile of chronic obstructive pulmonary disease in nonsmokers. Lung India 2017; 34(2): 122-6. DOI: https://doi.org/10.4103/0970-2113.201298
Shirakabe A, Hata N, Kobayashi N, et al. Worsening renal function definition is insufficient for evaluating acute renal failure in acute heart failure. ESC Heart Failure 2018; 5(3): 322-31. DOI: https://doi.org/10.1002/ehf2.12264
Trudzinski FC, Alqudrah M, Omlor A, et al. Consequences of chronic kidney disease in chronic obstructive pulmonary disease. Respiratory E+Research 2019; 20: 1-9. DOI: https://doi.org/10.1186/s12931-019-1107-x
Lai C-C, Wu C-H, Wang Y-H, Wang C-Y, Wu V-C, Chen L. The association between COPD and outcomes of patients with advanced chronic kidney disease. International Journal of Chronic Obstructive Pulmonary Disease 2018: 2899-905. DOI: https://doi.org/10.2147/COPD.S174215
Corsonello A, Aucella F, Pedone C, Antonelli‐Incalzi R. Chronic kidney disease: a likely underestimated component of multimorbidity in older patients with chronic obstructive pulmonary disease. Geriatrics & Gerontology International 2017; 17(11): 1770-88. DOI: https://doi.org/10.1111/ggi.13054
Fedeli U, De Giorgi A, Gennaro N, et al. Lung and kidney: a dangerous liaison? A population-based cohort study in COPD patients in Italy. International Journal of Chronic Obstructive Pulmonary Disease 2017: 443-50. DOI: https://doi.org/10.2147/COPD.S119390
Sorino C, Scichilone N, Pedone C, Negri S, Visca D, Spanevello A. When kidneys and lungs suffer together. Journal of Nephrology 2019; 32: 699-707. DOI: https://doi.org/10.1007/s40620-018-00563-1
Barakat M, McDonald H, Collier T, Smeeth L, Nitsch D, Quint J. Acute kidney injury in stable COPD and at exacerbation. International Journal of Chronic Obstructive Pulmonary Disease 2015: 2067-77. DOI: https://doi.org/10.2147/COPD.S88759
Koulouridis I, Price LL, Madias NE, Jaber BL. Hospital-acquired acute kidney injury and hospital readmission: a cohort study. American Journal of Kidney Diseases 2015; 65(2): 275-82. DOI: https://doi.org/10.1053/j.ajkd.2014.08.024
Gameiro J, Neves JB, Rodrigues N, et al. Acute kidney injury, long-term renal function and mortality in patients undergoing major abdominal surgery: a cohort analysis. Clinical Kidney Journal 2016; 9(2): 192-200. DOI: https://doi.org/10.1093/ckj/sfv144
Polverino F, Laucho-Contreras ME, Petersen H, et al. A pilot study linking endothelial injury in lungs and kidneys in chronic obstructive pulmonary disease. American Journal of Respiratory and Critical Care Medicine 2017; 195(11): 1464-76. DOI: https://doi.org/10.1164/rccm.201609-1765OC
Iwagami M, Mansfield K, Quint J, Nitsch D, Tomlinson L. Diagnosis of acute kidney injury and its association with in-hospital mortality in patients with infective exacerbations of bronchiectasis: cohort study from a UK nationwide database. BMC Pulmonary Medicine 2016; 16: 1-8. DOI: https://doi.org/10.1186/s12890-016-0177-5
Chao C-T, Wang J, Wu H-Y, Huang J-W, Chien K-L. Age modifies the risk factor profiles for acute kidney injury among recently diagnosed type 2 diabetic patients: a population-based study. Geroscience 2018; 40: 201-17. DOI: https://doi.org/10.1007/s11357-018-0013-3
Cao C-c, Chen D-w, Li J, et al. Community-acquired versus hospital-acquired acute kidney injury in patients with acute exacerbation of COPD requiring hospitalization in China. International Journal of Chronic Obstructive Pulmonary Disease 2018: 2183-90. DOI: https://doi.org/10.2147/COPD.S164648
Incalzi RA, Corsonello A, Pedone C, et al. Chronic renal failure: a neglected comorbidity of COPD. Chest 2010; 137(4): 831-7. DOI: https://doi.org/10.1378/chest.09-1710
Pelaia C, Pastori D, Armentaro G, et al. Predictors of renal function worsening in patients with chronic obstructive pulmonary disease (COPD): a multicenter observational study. Nutrients 2021; 13(8): 2811. DOI: https://doi.org/10.3390/nu13082811
Fabbian F, De Giorgi A, Manfredini F, et al. Impact of renal dysfunction on in-hospital mortality of patients with severe chronic obstructive pulmonary disease: a single-center Italian study. International Urology and Nephrology 2016; 48: 1121-7. DOI: https://doi.org/10.1007/s11255-016-1272-5
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